Quisinostat 2HCl

Name	Quisinostat (JNJ-26481585) 2HCl
Synonyms	JNJ26481585 Quisinostat 2HCl JNJ26854165 2HCL JNJ-26481585 2HCl Quisinostat dihydrochloride JNJ 26481585 dihydrochloride JNJ26854165(Quisinostat) 2HCl Quisinostat (JNJ-26481585) 2HCl JNJ 26481585 dihydrochloride - Quisinostat dihydrochloride
CAS	875320-31-3

Molecular Formula	C21H28Cl2N6O2
Molar Mass	467.39202
Storage Condition	-20℃
In vitro study	In Vitro, JNJ-26481585 effectively inhibits a group of recombinant HDAC enzymes, the most effective inhibition of HDAC1,IC50 0.11 nM, in addition to inhibit other family members such as HDAC2, 4, 10 and 11 when the effect is slightly lower, the IC50 was 0.33 nM, 0.64 nM, 0.46 nM and 0.37 nM, respectively. JNJ-26481585 acts on solid tumors and blood cancer cell lines, such as lung, breast, colon, prostate, brain, and ovarian cancer cell lines, with an IC50 of 3.1 to 246 nM, with broad-spectrum anti-proliferative activity, when acting on a variety of human cancer cell lines, the JNJ-26481585 effect is better than that of Vorinostat, R306465, Panobinostat, CRA-24781, and Mocetinostat. Recent studies have shown that JNJ-26481585 promotes bone marrow cancer cell death at low nanomolar concentrations by depleting Mcl-1 and inducing Hsp72 production.
In vivo study	JNJ-26481585 at the maximum tolerated dose (10 mg/kg intraperitoneal injection and 40 mg/kg oral treatment) for 3 days in the hdac1-sensitive A2780 ovarian cancer model, resulting in the production of hdac1-regulated fluorescence, measurable inhibition of tumor growth. Moreover, JNJ-26481585 was more effective than 5-fluorouracil/Leucovorin in inhibiting liver metastasis from C170HM2 colorectal cancer.

HS Code

29339900

Last Update：2024-01-02 23:10:35

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CAS: 875320-31-3
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Product Name: Quisinostat Dihydrochloride Request for quotation
CAS: 875320-31-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Product Name: Quisinostat (JNJ-26481585) 2HCl Visit Supplier Webpage Request for quotation
CAS: 875320-31-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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Quisinostat 2HCl

Quisinostat 2HCl Request for Quotation